Will This Prevent a Virus from Transferring?

First it is possible to virus can infect another hard drive. but it is possible when you can click on viruses file. But most of the virus file infect only a system file. You can only do to make a best dns scanner antivirus like avast, quickheal total security. you also protect your usb drive. time to time update your antivirus. And schdule the antivirus weekly.